Investment – Scott Loftesness

Bypassing the Leaf

For my entire life, I’ve understood the world through a simple, quiet equation: green plants take sunlight and air, and turn them into the stuff of life. It is a slow, terrestrial magic we all learn in grade school.

But lately, after listening to Professor Drew Endy at Stanford, I’ve been sitting with a curious yet exciting realization: that ancient equation is being rewritten.

Professor Endy champions a concept called electrobiosynthesis, or eBio. At its core, it represents the engineering of a parallel carbon cycle that operates independently of traditional photosynthesis.

The global industrial complex is approaching a transition point where our traditional reliance on extractive fossil fuels is being superseded by a regenerative, biological manufacturing paradigm.

For millennia, humanity has relied on the biological “middleman” of the plant to capture solar energy. But natural photosynthesis, for all its quiet beauty, is limited by severe biochemical constraints. Most commercial crops convert less than 1% of incident solar energy into usable biomass.

Electrobiosynthesis changes the math. By bypassing the plant entirely, we can utilize high-efficiency photovoltaics—which capture over 20% of the sun’s energy—to drive carbon fixation directly into the metabolic hubs of engineered microbes. This fixed carbon is transformed into organic molecules, serving as the feedstocks for high-value products like proteins and specialty chemicals.

In my own career, I’ve watched industries undergo profound, structural phase shifts. This really feels like another one of them. It seems that we are looking at a future where any molecule that can be encoded in DNA can be grown locally and on-demand. This fundamentally decouples manufacturing from centralized industrial nodes and fragile global supply chains.

The field appears to currently be in its “transistor moment,” moving from laboratory feasibility to industrial pilot plants. It signifies the ability to construct and sustain life-like processes without being restricted to the terrestrial lineage of photosynthesis.

Of course, with such foundational power comes the weight of unintended consequences. The ability to engineer life at this level brings severe biosecurity risks, and even the “Sputnik-like” strategic challenge of international competition in biotechnology. There are profound ethical dilemmas on the horizon, such as the creation of “mirror life”—organisms made from mirror-image biomolecules that might be invisible to natural ecosystems.

But the trajectory seems set. The vision described by Professor Endy—a world where we grow what we need, wherever we are, using only air and electricity—is no longer a distant science fiction. It is a nascent industrial reality. This future is being written not in sprawling factories, but in the microscopic architecture of the cell.

I’ve just now reading a deep research report on this whole area that I asked Google Gemini to create. It’s fascinating and I’ve discovered a whole new area (beyond AI) to explore further.

The Whetstone and the Hammock

We spend the first half of our lives trying to build a fortress of comfort, operating under the assumption that the ultimate reward for a lifetime of labor is the sudden, permanent cessation of it. We dream of the hammock. We dream of the empty calendar. But an empty calendar is really just a blank canvas with no paint.

Patrick O’Shaughnessy recently sat down with Paul Tudor Jones, and their conversation inevitably drifted toward the later chapters of life. Jones shared a story about fulfilling a promise to his wife to move to Palm Beach after their youngest child went to college. Upon arriving, she sent him to a local general practitioner—an 83-year-old doctor still seeing patients. Jones asked the man for the secret to longevity in a town (Palm Beach) he bluntly described as the “land of the walking dead.” The doctor’s response was a swift hammer blow:

“It’s real simple. You retire, you die.”

It’s a jarring diagnosis, but it cuts right to the bone.

We are biological machines designed for friction. Take away the resistance, and the gears don’t just stop; they rust.

Jones took the lesson to heart, noting that if you don’t use it, you lose it. He works out two hours a day and continues to trade, deliberately keeping his mind pressed against the whetstone of the markets.

I’ve watched this play out in my own circles over the years. I’ve seen brilliant, energetic colleagues hand over their keys, step out of the arena, and within months, seemingly deflate. The sudden absence of daily problems to solve doesn’t bring peace; it brings a creeping atrophy.

I’ve found myself deliberately holding onto certain complex projects and investments not because they are financially necessary, but because they demand my attention. They force me to wake up and solve a puzzle. They provide the necessary gravity to keep my feet on the ground.

But Jones offered a second, perhaps more profound reason for staying in the game. He wants to make “an absolute pot of money” specifically to give it away. He views his daily work not as a grind, but as the pursuit of nobility. He found a way to bridge the gap between the selfish need to keep his own mind sharp and the selfless desire to fuel the causes he cares about. The work becomes an engine for something larger than himself.

The hammock is a trap. The mind requires weight to bear, a horizon to move toward. The goal is not to finally lay down our tools, but to choose precisely what we want to build with them until the very end.

Stay hungry, stay foolish – and stay busy!

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