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Science Stanford

Bypassing the Leaf

For my entire life, I’ve understood the world through a simple, quiet equation: green plants take sunlight and air, and turn them into the stuff of life. It is a slow, terrestrial magic we all learn in grade school.

But lately, after listening to Professor Drew Endy at Stanford, I’ve been sitting with a curious yet exciting realization: that ancient equation is being rewritten.

Professor Endy champions a concept called electrobiosynthesis, or eBio. At its core, it represents the engineering of a parallel carbon cycle that operates independently of traditional photosynthesis.

The global industrial complex is approaching a transition point where our traditional reliance on extractive fossil fuels is being superseded by a regenerative, biological manufacturing paradigm.

For millennia, humanity has relied on the biological “middleman” of the plant to capture solar energy. But natural photosynthesis, for all its quiet beauty, is limited by severe biochemical constraints. Most commercial crops convert less than 1% of incident solar energy into usable biomass.

Electrobiosynthesis changes the math. By bypassing the plant entirely, we can utilize high-efficiency photovoltaics—which capture over 20% of the sun’s energy—to drive carbon fixation directly into the metabolic hubs of engineered microbes. This fixed carbon is transformed into organic molecules, serving as the feedstocks for high-value products like proteins and specialty chemicals.

In my own career, I’ve watched industries undergo profound, structural phase shifts. This really feels like another one of them. It seems that we are looking at a future where any molecule that can be encoded in DNA can be grown locally and on-demand. This fundamentally decouples manufacturing from centralized industrial nodes and fragile global supply chains.

The field appears to currently be in its “transistor moment,” moving from laboratory feasibility to industrial pilot plants. It signifies the ability to construct and sustain life-like processes without being restricted to the terrestrial lineage of photosynthesis.

Of course, with such foundational power comes the weight of unintended consequences. The ability to engineer life at this level brings severe biosecurity risks, and even the “Sputnik-like” strategic challenge of international competition in biotechnology. There are profound ethical dilemmas on the horizon, such as the creation of “mirror life”—organisms made from mirror-image biomolecules that might be invisible to natural ecosystems.

But the trajectory seems set. The vision described by Professor Endy—a world where we grow what we need, wherever we are, using only air and electricity—is no longer a distant science fiction. It is a nascent industrial reality. This future is being written not in sprawling factories, but in the microscopic architecture of the cell.

I’ve just now reading a deep research report on this whole area that I asked Google Gemini to create. It’s fascinating and I’ve discovered a whole new area (beyond AI) to explore further.

Categories
Atomic Energy Nuclear Energy Science

The Traffic Light That Split the Atom

If you wandered past the Mathematical Society and kept going, you’d come to a pedestrian crossing on Southampton Row where it meets Russell Square in London’s Bloomsbury. On a humid morning in September 1933, something world-changing happened there.

It was Tuesday, September 12. A cool, drizzling, quintessentially English autumn day. Leo Szilard — a brilliant, restless Hungarian-Jewish physicist who had fled Nazi Germany earlier that year — stood waiting at the traffic light. He was irritated, as people often are when a red light holds them up on a gray morning. He had been thinking about Ernest Rutherford’s recent lecture, in which the great pioneer of nuclear physics had dismissed the idea of extracting usable energy from the atom as “moonshine.”

Szilard disagreed. And as the light turned green and he stepped off the curb, the thought arrived in a flash.

What if a single neutron struck a nucleus and caused it to split, releasing two neutrons? Those two could split two more nuclei, releasing four — then eight, sixteen, thirty-two. In a large enough mass of the right material, the process could sustain itself — a chain reaction — and liberate enormous amounts of energy.

He saw it all in that instant: the possibility of limitless power, and the shadow of a weapon unlike anything the world had ever known.

Szilard was not in a laboratory. He was not surrounded by colleagues or equipment. He was simply crossing a London street, a refugee with too much on his mind, when the future opened up in front of him.

He filed a patent within the year and had it kept secret by the British Admiralty. He spent the rest of his life in the aftermath of that crossing — working on the first controlled chain reaction in Chicago in 1942, then becoming one of the most tireless advocates against the use of the weapons he had foreseen. The man who imagined the chain reaction spent decades trying to break it.

The spot where it happened remains utterly ordinary. Buses and taxis still rumble through the intersection. Tourists hurry toward the British Museum. Students cross on their way to Russell Square. There is no plaque. Szilard himself, given how deeply pacifist he became, might not have wanted one.

That feels right. The moment wasn’t grand or ceremonial. It was the kind of quiet, internal shift that happens when a prepared mind meets an ordinary irritation at a traffic light.

The hinges of history are fragile things, and they don’t announce themselves. Enormous consequences — nuclear power, the atomic bomb, the Cold War, decades of arms-control efforts — all trace back to one man’s realization while crossing a rainy London street. And once a thought like that arrives, it doesn’t leave. Szilard carried his for the rest of his life. He understood, earlier than almost anyone, both the dazzling promise and the terrible cost of what he had imagined at that crossing.

I came to this story through Sebastian Mallaby’s The Infinity Machine. It stopped me cold on the page, the way the best historical details do — not because it was dramatic, but because it was so ordinary.

Next time you’re stuck at a pedestrian light on a humid morning, pause for a moment. The light will change. You’ll step forward. But you never really know what might change with you.

Categories
Science

Remembering Zipf’s Law

A good friend of mine many years ago mentioned Zipf’s Law to me one time during a discussion. I remember being fascinated by it – named after the linguist George Kingsley Zipf – and then moving on as your brain so often does. This was years before the notion of the “long tail” and other such power law notions were demonstrated by the Internet, among other things.

Today, Steven Strogatz, a professor of applied mathematics at Cornell University, was the guest columnist for Olivia Judson’s “The Wild Side” blog on the New York Times site. His column, titled “Math and the City“, brought Zipf back to life again for me. If you’ve not read it, be sure to check it out – fascinating stuff!

Categories
San Francisco/California Science

The New California Academy of Sciences in Golden Gate Park

IMG_0205.jpgI attended a private event last night at the newly redone California Academy of Sciences in Golden Gate Park, San Francisco. The facility is truly amazing – compared to the stodgy (but still fun!) old building.

I wasn’t able to take the time to go through the Rain Forest – that’s apparently a special treat – but did get to watch the Fragile Planet show in the new version of the Morrison Planetarium – which claims to now be the largest all-digital planetarium on planet Earth.

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Science

The Mind that Changed The World

George Will’s column in today’s Washington Post is about Albert Einstein.

One hundred years ago a minor Swiss civil servant, having traveled home in a streetcar from his job in the Bern patent office, wondered: What would the city’s clock tower look like if observed from a streetcar racing away from the tower at the speed of light? The clock, he decided, would appear stopped because light could not catch up to the streetcar, but his own watch would tick normally. “A storm broke loose in my mind,” Albert Einstein later remembered.

Categories
Current Affairs Science

Progress in Health Care Economics

Alex Tabarrok writes about laser eye surgery being one example of great technology and market forces delivering very high patient satisfaction at declining prices as the market has expanded. I’ve not had the surgery but several of my friends who have are real evangelists for having it done.

Categories
Science

Capturing Fire

There’s a great story by Guy Gugliotta in this morning’s Washington Post about the discovery of controlled fire 790,000 years ago at a campsite on the banks of the Jordan River by a team from Hebrew University.

Regardless of researchers’ differences about who captured fire, or when, there is little argument that being able to control and use it marked a huge milestone in human evolution. Besides encouraging migration, fire also changed the human diet by making meat more palatable and vegetables softer and easier to eat. Humans grew larger and stronger.
Finally, and perhaps most importantly, fire enabled human ancestors to fend off marauders and feel comfortable and safe at night. Control of fire, said Harris and others, was a key innovation in helping transform humans from prey to predators.