I’ll second Derek Powazek’s recommendation of the Hotel Lucia as the place to stay when you’re in Portland. Another great spot, just around the corner, is Fifth Avenue Suites. Both are just a block or two from a MAX light rail station – which makes getting into town from PDX super simple – and cheap!
Last time I was in town, dinner at Serratto was a delight – an easy Portland Streetcar ride from the hotel. Or, do what I did, and walk a couple of blocks from the hotel north to Powell’s Books, browse until it’s dinnertime, and then grab the Streetcar to Serratto’s!